Figure 1.
![Figure 1. CD45RO+ myeloma cells responded to IL-6 by proliferating. (A) Expression profiles of CD45 isoforms in myeloma and normal plasma cells from bone marrow aspirate of a representative myeloma patient and healthy donor were analyzed by flow cytometry. CD38++ CD45+ cells (regions a and b) were analyzed with CD45RA, CD45RB, or CD45RO antibody. (B) Incorporation of [3H]-TdR into normal plasma cells (region a in panel A), and CD45+ and CD45- immature myeloma cells (regions b and c) isolated from a healthy donor and myeloma patient, respectively, by the cell sorter in the presence (▪) or absence (□) of IL-6 (n = 5). FS indicates forward scatter; SS, side scatter.](https://ash.silverchair-cdn.com/ash/content_public/journal/blood/105/8/10.1182_blood-2004-10-4083/6/zh80080576950001.jpeg?Expires=1735573073&Signature=Y~w0eDIdYCDWGiAs35lgkyrKM5KyfPAvEvdHVDA5J-DGQyPjCO-tpOHR1AyZsg5XkBBWTcY6DVKZW~epbOwQ8qMDmto9kvVmjaOlfUlwAQZS7QuS8FYnjiN3amaEw44pFsr8kK30PbHETWPW6dxyskhp0z92JIae8aFoPRatjTFMlt4wZJ-jnRdz22d~T~MzK7YKpNJQ5fEfZhVSDkTPwO04jHwWKzjefTZMzIVphe8ORJ3aXE2dgFEWLfuFn3JMhH3suXmuC1ieegfcXh4q5AizHQ4X8e0DAEcc9vBp8zoVWtPu5ZLT7mWTexUc-gwQXN6TVxD7H2M69MGZaEHgDQ__&Key-Pair-Id=APKAIE5G5CRDK6RD3PGA)
CD45RO+ myeloma cells responded to IL-6 by proliferating. (A) Expression profiles of CD45 isoforms in myeloma and normal plasma cells from bone marrow aspirate of a representative myeloma patient and healthy donor were analyzed by flow cytometry. CD38++ CD45+ cells (regions a and b) were analyzed with CD45RA, CD45RB, or CD45RO antibody. (B) Incorporation of [3H]-TdR into normal plasma cells (region a in panel A), and CD45+ and CD45- immature myeloma cells (regions b and c) isolated from a healthy donor and myeloma patient, respectively, by the cell sorter in the presence (▪) or absence (□) of IL-6 (n = 5). FS indicates forward scatter; SS, side scatter.
