Expression of activated B-cell profile and germinal center profile genes in primary cutaneous large B-cell lymphoma. Hierarchical clustering analysis of primary cutaneous follicle center cell lymphoma (PCFCCL) and primary cutaneous large B-cell lymphoma of the leg (PCLBCL-leg) was performed based on the expression of 43 genes present in a recently described list consisting of 43 genes that discriminate between activated B-cell (ABC) and germinal center B-cell (GCB) types of diffuse large B-cell lymphoma with highest significance.27 These 43 genes were identified previously using the Affymetrix HU6500 microarray after the assignation of 274 DLBCL to ABC type or GCB type using a predictor model based on 14 genes represented on the Affymetrix HU6500 microarray of 27 predictor genes of the lymphochip. Hierarchical clustering based on these 43 selected genes clustered, respectively, 7 of 8 PCFCCL and 13 of 13 PCLBCL-leg in 2 distinct groups.
