Figure 5.
Figure 5. CD47-/- mice are more sensitive to experimental ITP. Experimental ITP was induced in CD47+/+ and CD47-/- C57BL /6 or Balb/c mice, using the pathogenic IgG2a anti–mouse platelet mAb 6A6. (A) Dose-dependent effect of 6A6 in CD47+/+ mice. (B) CD47+/+ (⬡) or CD47-/- (○) C57BL /6 mice were injected with 6A6 at 0.1 μg/g body weight. Baseline platelet counts were 1179 ± 94 × 109 platelets/L for CD47+/+ mice and 980 ± 42 × 109 platelets/L for CD47-/- mice. (C) CD47+/+ (▪)or CD47-/- (□) Balb/c mice were injected with 6A6 at 0.1 μg/g body weight. Baseline platelet counts were 1332 ± 40 × 109 platelets/L for CD47+/+ mice and 1029 ± 122 × 109 platelets/L for CD47-/- mice. Data are means ± SEMs for 4 to 6 mice in each group. *P < .05 and **P < .01, as compared with CD47+/+ mice, using Student t test for unpaired samples.

CD47-/- mice are more sensitive to experimental ITP. Experimental ITP was induced in CD47+/+ and CD47-/- C57BL /6 or Balb/c mice, using the pathogenic IgG2a anti–mouse platelet mAb 6A6. (A) Dose-dependent effect of 6A6 in CD47+/+ mice. (B) CD47+/+ (⬡) or CD47-/- (○) C57BL /6 mice were injected with 6A6 at 0.1 μg/g body weight. Baseline platelet counts were 1179 ± 94 × 109 platelets/L for CD47+/+ mice and 980 ± 42 × 109 platelets/L for CD47-/- mice. (C) CD47+/+ (▪)or CD47-/- (□) Balb/c mice were injected with 6A6 at 0.1 μg/g body weight. Baseline platelet counts were 1332 ± 40 × 109 platelets/L for CD47+/+ mice and 1029 ± 122 × 109 platelets/L for CD47-/- mice. Data are means ± SEMs for 4 to 6 mice in each group. *P < .05 and **P < .01, as compared with CD47+/+ mice, using Student t test for unpaired samples.

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