FANCG mutation and SNP. (A) Sequence of part of exon 5 of the FANCG gene showing the c.637_643delTACCGCC mutation (637-643del). (B) PCR assay for the FANCG deletion. Samples from African FA patients; the final 2 lanes are a heterozygote and a normal control, respectively. The normal allele is 105 bp in length and the mutant allele 98 bp. (C) Sequence of part of intron 1 of the FANCG gene showing the c.84 + 77A > C SNP (IVS1 + 77A > C).