Effect of HLJDT, GZFLW, or HLT on proliferation of myeloma cell lines. U266 cells were cultured without IL-6 (A) or with IL-6 at 2 ng/mL (B) in the presence of HLJDT (•), GZFLW (▴), or HLT (♦) at the indicated concentration for 4 days. Cell viability was assessed by flow cytometric detection of FS/SS as described in “Patients, materials, and methods.” (C) ILKM-2, an IL-6-dependent myeloma cell line, was cultured with IL-6 at 2 ng/mL in the presence of HLJDT, GZFLW, or HLT at the indicated concentration for 4 days. AMO1 (D) or NOP-2 cells (E), IL-6-independent myeloma cell lines, were also cultured. Viable cell number was assessed by flow cytometric detection of FS/SS. Values shown in these figures are the mean ± 1 SD of 3 independent experiments. ^*P < .05, ^**P < .01.