American Society of Hematology

Figure 6.

$Figure 6. Effect of baicalein, baicalin, or wogonin on the survival of primary myeloma cells in vitro. Bone marrow mononuclear cells from 9 myeloma patients were cultured with baicalein (⋄), baicalin (□), or wogonin (▵) in the presence of 5 ng/mL of IL-6 at the indicated concentration for 2 days. After the culture, the cells were harvested, stained with FITC-anti-CD38, PE-anti-MPC-1, and PC5-anti-CD45 antibodies and applied to a flow cytometer. Viable cell numbers of CD38++ (left), CD38++MPC-1- (middle), and CD38++MPC-1+ fractions (right) were examined, and compared with those in medium alone (DMSO control; 100%). Values shown in these figures are the mean ± 1 SD of 9 cases. *P < .05, **P < .01.$

Effect of baicalein, baicalin, or wogonin on the survival of primary myeloma cells in vitro. Bone marrow mononuclear cells from 9 myeloma patients were cultured with baicalein (⋄), baicalin (□), or wogonin (▵) in the presence of 5 ng/mL of IL-6 at the indicated concentration for 2 days. After the culture, the cells were harvested, stained with FITC-anti-CD38, PE-anti-MPC-1, and PC5-anti-CD45 antibodies and applied to a flow cytometer. Viable cell numbers of CD38⁺⁺ (left), CD38⁺⁺MPC-1^- (middle), and CD38⁺⁺MPC-1⁺ fractions (right) were examined, and compared with those in medium alone (DMSO control; 100%). Values shown in these figures are the mean ± 1 SD of 9 cases. ^*P < .05, ^**P < .01.

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