SiRNA knocks down the surface expression of Fas in EBV-CTLs. EBV-CTLs transduced with the EV (A), CsiRNA (B), siRNA10 (C), or with both siRNA10 and GFP-siRNA8 (siRNA10 and 8) (D) after selection were stained with anti-CD95-PE (solid lines) or isotype control (dashed lines). Bold solid lines and thin solid lines indicate CD95 expression in EBV-CTLs nontransduced (NT) and transduced, respectively. (E) The CD95 MFI in EBV-CTLs NT and transduced with the different vectors. Data represent the mean ± SD of 6 different donors (^*P < .001). (F) The percentage of apoptotic EBV-CTLs is shown after incubation with (▦) or without (□) CH-11 antibody (40 ng/mL). Data represent the mean ± SD of 5 different donors (^**P = .006).