Lymphatic capillary hyperplasia in K14-Ang1 transgenic mice. (A-B) Lymphatic vessels in the ear of a K14-Ang1 transgenic mouse (A) and littermate control (B) whole-mount-stained with antibodies to LYVE-1. Note lymphatic vessels around hair follicles (arrowheads). (C-D) Double staining of lymphatic (red) and blood vessels (green). (E) Quantitative analysis of the circumference of LYVE-1-stained lymphatic vessels in ear sections (see micrographs to the left of the graph) of K14-Ang1 transgenic mice relative to controls. Bars represent mean values ± SD (n = 3) and P < .01 compared with wild-type (WT) controls. Scale bars: 100 μm.