Expansion of FANCC-expressing BM lin^– cells exposed to hyperoxic-hypoxic-hyperoxic treatment. (A) Proportions of transduced (GFP⁺) cells in GFP and FANCC/GFP cultures. The increase in GFP⁺ cells in the FANCC/GFP culture reflects a growth advantage conferred by FANCC expression. Data are the mean ± SD of triplicate determinations. *Statistical significance between day 5 and day 10 samples at P < .05. (B) Growth of clonogenic progenitors (CFC) of nontransduced and transduced Fancc^–/– BM lin^– cells. Note that while the proportion of GFP⁺ CFCs decreased in reoxygenated GFP culture, the GFP⁺ CFCs were dramatically increased in the FANCC/GFP culture. Data are the mean ± SD of triplicate determinations. *Statistical significance between untreated (Con) and treated (Reoxy) samples at P < .01.