DNA damage in T-cell subsets during HIV infection. Accumulation of 8-oxoG in (A) CD4⁺ and (B) CD8⁺ T cells from HIV-infected patients. Nuclear DNA was isolated from T-cell subsets of AIDS patients (n = 5), HIV-infected patients (n = 4), and healthy controls (n = 7). Levels of 8-oxoG were quantified by HPLC-ECD after enzymatic DNA hydrolysis. ^*P < .05 compared with healthy controls; #P < .05 compared with patients without AIDS. Data are given as medians and as 25th to 75th percentiles.