Bone marrow histology in a patient with Gaucher disease and multiple myeloma. Bone marrow biospsy obtained at the time of diagnosis of multiple myeloma in a 56-year-old male patient with Gaucher disease. (Left panel) Small areas containing Gaucher cells (arrows). (Right panel) Extensive infiltration with abnormal plasmacytoid lymphocytes and plasma cells (hematoxylin and eosin; original magnification ×1000; Olympus BH-2). Immunostaining was positive for CD38, immunoglobulin G, and lambda. Karyotyping revealed no chromosomal rearrangements. (Courtesy of Dr Margaret E. Rick, Hematology Service, Department of Laboratory Medicine, Clinical Center, National Institutes of Health, Bethesda, MD.)

Bone marrow histology in a patient with Gaucher disease and multiple myeloma. Bone marrow biospsy obtained at the time of diagnosis of multiple myeloma in a 56-year-old male patient with Gaucher disease. (Left panel) Small areas containing Gaucher cells (arrows). (Right panel) Extensive infiltration with abnormal plasmacytoid lymphocytes and plasma cells (hematoxylin and eosin; original magnification ×1000; Olympus BH-2). Immunostaining was positive for CD38, immunoglobulin G, and lambda. Karyotyping revealed no chromosomal rearrangements. (Courtesy of Dr Margaret E. Rick, Hematology Service, Department of Laboratory Medicine, Clinical Center, National Institutes of Health, Bethesda, MD.)

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