Schematic diagram of ADAM and ADAMTS metalloproteases and of ADAMTS13. SP indicates signal peptide; pro, propeptide; protease, metalloprotease (location of zinc-binding motif shown in red); disintegrin, disintegrin domain; dis-like, disintegrin-like domain; cys-rich, cysteine-rich domain; TSP, thrombospondin type-1 motif; EGF, epidermal growth factor-like repeat; TM, transmembrane domain; CUB, CUB domain.