Recipients of CD4⁺ naive T cells from CCR6-deficient donors have lower, delayed expression of proinflammatory cytokines and chemokines in GvHD target organs. Cytokine and chemokine transcript levels (indicated) were measured over time by real-time quantitative RT-PCR in skin (A) and small intestine (B) of naive T-cell recipients from WT (○) and CCR6-deficient (□) donors. Data represent the mean ± SD (n = 2-4 mice/group/time-point) and illustrate the x-fold up-regulation observed in mice that received transplants versus mice that did not receive transplants.