Figure 7.
Targets of dexamethasone in CD34+cells were identified by oligonucleotide microarrays. (A) The effect of dexamethasone on the expression of key hematopoietic genes was analyzed in cells grown in the presence of Epo and SCF. The fold change in gene expression in response to dexamethasone at 18 and 48 hours of culture is shown for each gene. (B) Rows correspond to the genes most significantly up-regulated and down-regulated by dexamethasone across cytokine conditions. Each column is a different microarray experiment of CD34+ cells grown for 18 hours in the presence of the indicated cytokines with or without dexamethasone. Table S5 contains a list of genes induced by dexamethasone.