Figure 2.
Figure 2. A2A agonists, but not agonists of other adenosine receptor subtypes, directly inhibit Th1/Tc1 cell IL-2 secretion. T1 and T2 cells (0.5 × 106/mL) were restimulated on day 5 of culture with 3/28 beads in the presence of either low-dose adenosine receptor agonist (10-9 M; □) or high-dose agonist (10-7 M; ▪), including A1 receptor agonist (CPA), A2A receptor agonist (CGS), A2A and A2B receptor agonist (NECA), and A3 receptor agonist (Cl-IB). After 24 hours, the resultant supernatants were evaluated for cytokine content by ELISA.

A2A agonists, but not agonists of other adenosine receptor subtypes, directly inhibit Th1/Tc1 cell IL-2 secretion. T1 and T2 cells (0.5 × 106/mL) were restimulated on day 5 of culture with 3/28 beads in the presence of either low-dose adenosine receptor agonist (10-9 M; □) or high-dose agonist (10-7 M; ▪), including A1 receptor agonist (CPA), A2A receptor agonist (CGS), A2A and A2B receptor agonist (NECA), and A3 receptor agonist (Cl-IB). After 24 hours, the resultant supernatants were evaluated for cytokine content by ELISA.

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