Figure 6.
Figure 6. Adenosine A2A receptor agonism reduces IL-2 while preserving IFN-γ secretion at the single-cell level. Costimulated Th1/Tc1 cells were generated, and restimulated on day 6 of culture in media containing DMSO vehicle control (A) or the adenosine A2A receptor agonist CGS (10-7 M; B). Four hours after stimulation, T cells were harvested and subjected to cytokine capture flow cytometry. The percentages of T cells secreting only IL-2, only IFN-γ, or both IL-2 and IFN-γ are shown in the dot plot.

Adenosine A2A receptor agonism reduces IL-2 while preserving IFN-γ secretion at the single-cell level. Costimulated Th1/Tc1 cells were generated, and restimulated on day 6 of culture in media containing DMSO vehicle control (A) or the adenosine A2A receptor agonist CGS (10-7 M; B). Four hours after stimulation, T cells were harvested and subjected to cytokine capture flow cytometry. The percentages of T cells secreting only IL-2, only IFN-γ, or both IL-2 and IFN-γ are shown in the dot plot.

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