SCID mice reconstituted with transduced BM cells can control the growth of the MUC1-positive tumor xenograft. (A) Control (▴) or scTCR-reconstituted (○) mice were injected subcutaneously with 2 × 106 HPAF (MUC1-positive) tumor cells. Tumor size is shown on the y-axis while days after tumor challenge is plotted on the x-axis. P values were calculated by running t test using Microsoft Excel software. Data are presented as mean ± SE. (B) H&E staining of HPAF tumor sections from control mice (left) or from scTCR-reconstituted mice (right). (C) Staining of tumor sections from scTCR-reconstituted mice for myeloperoxidase (neutrophil marker), F4/80 (monocyte/macrophage marker), or granzyme B (NK cell marker). Images were taken under × 20 magnification. Images in lower right squares were taken under × 100 magnification.
