scTCR-reconstituted MUC1 Tg mice rejected MUC1-positive tumor challenge. MUC1 Tg mice were reconstituted with BM cells transduced with scTCR (▴) or with control supernatant (▪) and challenged 6 weeks later with MUC1^- tumor (RMA) or with RMA cells transfected with MUC1 (RMA-MUC1). Data are presented as mean ± SE. The number of mice at each time point ranged from 5 to 10.