Figure 5.
Autoimmunity can be transferred in syngeneic recipients. Lethally irradiated (900 cGy) Balb mice received transplants of TCD B6 BM plus 3 × 105 B6 spleen cells. Spleen cells were obtained from GVHD animals 22 days after BMT and transferred into B6 Rag recipients for 67 days. Mice were then killed, and pooled spleen cells were transferred into either B6 or Balb Rag animals (n = 4/group). Mice were killed 61 days after transfer and analyzed for overall spleen cellularity (A), absolute number of splenic T cells (B), and incidence of colitis (C). Data are presented as the mean ± SEM.
