American Society of Hematology

Figure 2.

$Figure 2. MLN-deficient mice are refractory for the induction of cross-tolerance toward intestinal OVA. We injected 200 μgLTβR-Ig or LTβR-Ig/TNFR55-Ig to timed pregnant mice to generate PP-null or PP/MLN-double deficient mice, respectively (see Supplemental Figure S1). The offspring mice were given 25 mg intragastric OVA or PBS then primed with OVA-loaded splenocytes. Seven days after priming, CTL assay was performed. The mean value of the lytic unit is expressed as a bar. *P < .05 in comparison with PBS-treated group. Data are representative of 2 experiments.$

MLN-deficient mice are refractory for the induction of cross-tolerance toward intestinal OVA. We injected 200 μgLTβR-Ig or LTβR-Ig/TNFR55-Ig to timed pregnant mice to generate PP-null or PP/MLN-double deficient mice, respectively (see Supplemental Figure S1). The offspring mice were given 25 mg intragastric OVA or PBS then primed with OVA-loaded splenocytes. Seven days after priming, CTL assay was performed. The mean value of the lytic unit is expressed as a bar. *P < .05 in comparison with PBS-treated group. Data are representative of 2 experiments.

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