Trisomy of chromosomes 3, 5, 7, 9, 11, 15, 19, and 21 in D1 group. (A) Chromosome localization of genes overexpressed in D1 group and in hyperdiploid ALL. For both the hyperdiploid greater than 50 subgroup of ALL and the D1 group of MM, a list of 618 (ALL) or 545 (MM) genes overexpressed within that group, compared with all other patients with ALL or MM, was generated. From these lists, the ratio of the number of observed to expected genes from each chromosome is plotted. (B) Chromosome index in ALL and MM. For each patient, a chromosome index was calculated for each chromosome using the median level of expression of the genes on that chromosome and plotted with chromosome 1 at the top, down to X at the bottom. No index was calculated for chromosome Y. For the MM samples, this chromosome index was normalized to the median value in BMPCs. A color scale on the left indicates red above 1.3, yellow for 1, and green below 0.7. Patients with MM are grouped as described in Figure 1. The patients with ALL are grouped based on the genetics as described in Yeoh et al²⁰  (TEL, T, normal, MLL, hyperdiploid, EZA, BCR). See also Supplemental Worksheet, data for Figure 3.