Figure 4.
A model of intravascular metabolism of NO. NO produced by eNOS may diffuse into the vascular lumen as well as the underlying smooth muscle. The majority of this NO enters the erythrocyte and reacts with oxyhemoglobin (Oxy Hb) to form nitrate ( \(\mathrm{N}\mathrm{O}_{3}^{-}\)
); a minor portion may escape the hemoglobin scavenger and react with plasma constituents to form nitros(yl)ated species (RXNO, nitrosothiols: RSNO), nitrated lipids (NO2 lipids), and nitrite ( \(\mathrm{N}\mathrm{O}_{2}^{-}\)
). Each of these species is capable of transducing NO bioactivity far from its location of formation. Nitrite may diffuse into the erythrocytes where it appears in a higher concentration than in plasma. In the erythrocyte nitrite reacts with deoxyhemoglobin (Deoxy Hb) to form nitric oxide and methemoglobin (Met Hb) and other NO adducts. NO can then either diffuse out of the erythrocyte directly or via an intermediate NO metabolite. The question mark circled in white refers to the possibility of an intermediate during nitrite bioactivation. NO Hb indicates iron nitrosylhemoglobin; SNO Hb, nitrosohemoglobin; L-Arg, L-arginine; L-Cit, L-citrulline; NxOy: higher N oxides.
![Figure 4. A model of intravascular metabolism of NO. NO produced by eNOS may diffuse into the vascular lumen as well as the underlying smooth muscle. The majority of this NO enters the erythrocyte and reacts with oxyhemoglobin (Oxy Hb) to form nitrate (\batchmode \documentclass[fleqn,10pt,legalpaper]{article} \usepackage{amssymb} \usepackage{amsfonts} \usepackage{amsmath} \pagestyle{empty} \begin{document} \(\mathrm{N}\mathrm{O}_{3}^{-}\) \end{document}); a minor portion may escape the hemoglobin scavenger and react with plasma constituents to form nitros(yl)ated species (RXNO, nitrosothiols: RSNO), nitrated lipids (NO2 lipids), and nitrite (\batchmode \documentclass[fleqn,10pt,legalpaper]{article} \usepackage{amssymb} \usepackage{amsfonts} \usepackage{amsmath} \pagestyle{empty} \begin{document} \(\mathrm{N}\mathrm{O}_{2}^{-}\) \end{document}). Each of these species is capable of transducing NO bioactivity far from its location of formation. Nitrite may diffuse into the erythrocytes where it appears in a higher concentration than in plasma. In the erythrocyte nitrite reacts with deoxyhemoglobin (Deoxy Hb) to form nitric oxide and methemoglobin (Met Hb) and other NO adducts. NO can then either diffuse out of the erythrocyte directly or via an intermediate NO metabolite. The question mark circled in white refers to the possibility of an intermediate during nitrite bioactivation. NO Hb indicates iron nitrosylhemoglobin; SNO Hb, nitrosohemoglobin; L-Arg, L-arginine; L-Cit, L-citrulline; NxOy: higher N oxides.](https://ash.silverchair-cdn.com/ash/content_public/journal/blood/106/2/10.1182_blood-2005-02-0567/6/zh80140581330004.jpeg?Expires=1735522901&Signature=CDkJQFsxlLNteCkgLjoOL7Mgayd~yXIHVlykSRDTWeyEIGw0cDIv~P8aN2~AgaWD4dNQ7S7CKyMX64U6SadarjZizKzoOsRUc4AkNlSO7M2NZTYSdU1ld3I3k9VqpKVsVE77tec1CzG~G26BvsOai9FCFZ8ahz-D4~oJXyd07Nanf0g82DnFqM8VAJ4EWwB~i0b2dAaiTFocukCpDAzRty0idhE3V~ie0qjKDcINtWDOTccSgRZVaDOUWhTRFpifgfto2yDwOy2tqaDeigLkK~5HVJbVTt~7uH-ppILBzOrHi45S7oK7R4mk08Ic8-OPuUTfBqd1W6LBTc2i0hv55w__&Key-Pair-Id=APKAIE5G5CRDK6RD3PGA)
