B-cell recovery and granulocyte dynamics. Flow cytometric quantitation of circulating B cells and granulocytes was performed in 24 patients with mantle cell lymphoma. (A) The kinetics of B-cell recovery following DA-EPOCH-R is shown. Before treatment, both normal and neoplastic B cells were present. After treatment, only normal circulating B cells were present. B-cell recovery of more than 40 cells/mm³ was achieved in 14 of 21 evaluable patients at 9 months and in 23 of 24 patients at 12 months. Horizontal lines in bars represent the 50th percentile (median). Error bars represent the 90th percentile (above) and 10th percentile (below). Open circles indicate outliers greater than the 90th and less than the 10th percentiles. (B) Between 3 and 9 months after treatment, the change (Δ) in B cells inversely correlated with the change in granulocytes, indicating that rapid B-cell recovery is associated with a fall in circulating granulocytes (R = –0.53; P = .04). • designates the 2 patients with LON.