Simulation of cases of late-onset neutropenia. Simulation of the occurrence of LON in 9 patients up to an observation period of 210 days. Boxes represent individual episodes of LON, with the dashed areas showing undetected periods and shaded areas showing detected periods of LON. The vertical bars show routine blood counts obtained at 90 and 180 days. Note that 6 of the 9 cases of LON went entirely undetected, and even in cases in which LON was detected, the true duration of neutropenia was often significantly longer than the observed duration.