Low doses of R-etodolac induce up-regulation of Mcl-1_s and Dex-induced apoptosis in MM cells. (A) MM.1S cells were cultured with R-etodolac at the indicated doses for 24 hours. (B) MM.1S cells were cultured with R-etodolac (0.6 mM) for the indicated times. (C) MM.1S cells were cultured for 24 hours with control media or 1.0 μM Dex, in the presence or absence of R-etodolac (0.15 or 0.3 mM). Total cell lysates were subjected to Western blotting using anti-caspase-8, -caspase-9, -PARP, -Bax, -Bcl-2, -Bcl-xL, -Mcl-1, and -α-tubulin Abs.