Figure 7.
![Figure 7. R-etodolac overcomes the growth stimulatory effects of IL-6, IGF-1, and BMSCs. MM.1S (A) and RPMI8226 (B) MM cells were cultured for 24 hours with control media (□) and with 0.3 mM (▦), 0.6 mM (▨), or 1.25 mM (▪) R-etodolac, in the presence or absence of IL-6 (25 ng/mL) and IGF-1 (50 ng/mL). MM.1S cells, 2 different patient BMSCs (BMSC no. 1 [C] and BMSC no. 2 [D]), or both MM.1S cells and BMSCs were cultured for 24 hours with control media (□), and with 0.3 mM (▦), 0.6 mM (▨), or 1.25 mM (▪) R-etodolac. Cell growth was assessed by [3H]-thymidine uptake, and data represent mean (± SD) of quadruplicate cultures. *P < .01.](https://ash.silverchair-cdn.com/ash/content_public/journal/blood/106/2/10.1182_blood-2005-02-0838/6/zh80140581360006.jpeg?Expires=1735527230&Signature=TzZZINjQWdTHLkAoSrpB~OIg4oyo1hMB1nFVdnDgksLgA6g1ZpjvaAYOUslxHRn8QmiUgI0nGy~H5qgbCSDatgp1WtkjcfN0EV34vaamRlbUFC9SmA6zVbNouO--inmaVPZr0JzVSD1hTArSVvd4kaShKr8jC4ztdvLE5N1Le4Y660N9OOiuMteXEtHsqezJM2T8PJ1Z9CCd2vaU0hzkwpSGXuI0LsHmlZrAElDd4iABbwNzY9fNaEb3qwCD8oowWyqfL0pQf1ge4IE76u~uTFTfjkjvagX-M0G79em55-q89pBOfR9oJ19JySNuUN~DO3tLlRuRnn9lhzFUQw4j7Q__&Key-Pair-Id=APKAIE5G5CRDK6RD3PGA)
R-etodolac overcomes the growth stimulatory effects of IL-6, IGF-1, and BMSCs. MM.1S (A) and RPMI8226 (B) MM cells were cultured for 24 hours with control media (□) and with 0.3 mM (▦), 0.6 mM (▨), or 1.25 mM (▪) R-etodolac, in the presence or absence of IL-6 (25 ng/mL) and IGF-1 (50 ng/mL). MM.1S cells, 2 different patient BMSCs (BMSC no. 1 [C] and BMSC no. 2 [D]), or both MM.1S cells and BMSCs were cultured for 24 hours with control media (□), and with 0.3 mM (▦), 0.6 mM (▨), or 1.25 mM (▪) R-etodolac. Cell growth was assessed by [3H]-thymidine uptake, and data represent mean (± SD) of quadruplicate cultures. *P < .01.
