Figure 7.
Figure 7. Egr-1 partially rescues BKS-2 B-lymphoma cells from SP600125-induced apoptosis, and Bcl-xL antagonizes apoptosis induced by SP600125 in WEHI-231 B-lymphoma cells. (A) Hoechst analysis of BKS-2 cells expressing control vector (GFP alone) or Egr-1 in the presence or absence of 5 μM SP600125 at 48 hours. (B) Same as in panel A except for analysis by annexin V and PI staining for apoptotic cells. (C) PI analysis of WEHI-231 or WEHI-231 stably transfected with Bcl-xL (WEHI-Bcl-xL) in the presence or absence of 10 μM SP600125. Results are presented as means ± SE of triplicate cultures. Similar results were obtained in 2 other experiments.

Egr-1 partially rescues BKS-2 B-lymphoma cells from SP600125-induced apoptosis, and Bcl-xL antagonizes apoptosis induced by SP600125 in WEHI-231 B-lymphoma cells. (A) Hoechst analysis of BKS-2 cells expressing control vector (GFP alone) or Egr-1 in the presence or absence of 5 μM SP600125 at 48 hours. (B) Same as in panel A except for analysis by annexin V and PI staining for apoptotic cells. (C) PI analysis of WEHI-231 or WEHI-231 stably transfected with Bcl-xL (WEHI-Bcl-xL) in the presence or absence of 10 μM SP600125. Results are presented as means ± SE of triplicate cultures. Similar results were obtained in 2 other experiments.

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