Donor-recipient origin of different peripheral blood and marrow cell populations at 4 years after transplantation.

The percentage of donor chimerism in the blood and marrow nucleated cells is shown in A. β-globin chain synthesis by marrow and reticulocytes was greater than 90% at 4 years after transplant. Although there is an enrichment for donor cells in the mature red blood cell compartment as demonstrated by the high rate of β-globin synthesis, the percentage of donor cells in the immature red blood cell compartment (BFU-E and glycophorin-A positive cells) was approximately 20% (in B).