Absence of nonspecific effects on related chemokine receptors. No nonspecific effects were observed on peritoneal macrophage mRNA levels of other chemokine receptors, as CCR3 (A), CCR5 (B), and CXCR3 (C) in mice that underwent transplantation with H1.shCCR2 lentivirus–transduced bone marrow compared with the H1.Empty controls. Ccr2^–/– bone marrow transplantation led to a significant decrease in macrophage CCR5 expression (P = .04). ▵Ct indicates delta cycle threshold.