American Society of Hematology

Figure 4.

$Figure 4. S1P1–/– T cells display a defect in integrin-mediated firm arrest in PLN HEVs. The intravascular behavior of calcein-labeled CD4+ SP cells from S1P1+/ or S1P1–/– FL chimeras was analyzed by IVM in inguinal LN of WT mice (n = 2 mice). (A) Rolling and (B) sticking fractions (44.1% ± 5.6% of S1P1+/ versus 26.5% ± 6.2% of S1P1–/–; *P < .05) of cells were determined in venular orders III, IV, and V. Error bars indicate SEM.$

S1P₁^–/– T cells display a defect in integrin-mediated firm arrest in PLN HEVs. The intravascular behavior of calcein-labeled CD4⁺ SP cells from S1P₁^+/ or S1P₁^–/– FL chimeras was analyzed by IVM in inguinal LN of WT mice (n = 2 mice). (A) Rolling and (B) sticking fractions (44.1% ± 5.6% of S1P₁^+/ versus 26.5% ± 6.2% of S1P₁^–/–; *P < .05) of cells were determined in venular orders III, IV, and V. Error bars indicate SEM.

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