PEP005 induces apoptosis and differentiation in leukemic cell lines. There were 5 leukemic cell lines treated with PEP005 for 5 days. (A-B) Differentiation was assessed by expression of CD11b and (C-D) apoptosis was assessed by entry of cells into a subdiploid phase. Differentiation and apoptosis were also measured in response to PEP005 and PMA after 3 days by assessing phagocytosis of yeast (E) and caspase-3 activity (F). Data in panels A and E are expressed as mean ± standard deviation.