HSC (top) versus MSC (bottom) transplant for treatment of EAE. The top panel shows the therapeutic effect of HSCT in EAE requires an immune suppressive conditioning regimen. No response from infusion of only bone marrow (BMT) without a conditioning regimen. Reprinted from Burt et al.6 (Fig1) The bottom panel shows the therapeutic effect of MSC occurs without any chemotherapy; see the complete figure in the article beginning on page 1755.