Socs1^lox/-LysM-cre mice succumb to a multiorgan inflammatory disease. Representative hematoxylin and eosin-stained sections of the (A,E) liver, (B,F) pancreas, (C,G) lung, and (D,H) spleen from (A-D) moribund Socs1^lox/-LysM-cre mice and (E-H) healthy Socs1^lox/- nontransgenic littermates. Frozen sections of liver from moribund Socs1^lox/-LysM-cre mice were stained with antibodies recognizing (I) CD4, (J) CD8, and (K) CD11b. (L) Splenocytes and (M) blood leukocytes from moribund Socs1^lox/-LysM-cre and age-matched Socs1^lox/- nontransgenic mice were analyzed for expression of the indicated markers by flow cytometry. Quadrant percentages are shown.