Targeting SOCS-1 deficiency to hepatocytes exacerbates the hepatocyte damage in Socs1^lox/-LysM-cre mice. (A) Survival curves of Socs1^lox/-Alb-cre (▴; n = 6), Socs1^lox/-Alb-cre/LysM-cre (▪; n = 14), and Socs1^lox/-Alb-cre/Lck-cre (•; n = 6) mice. (B) Liver pathology in Socs1^lox/-Alb-cre/LysM-cre mice compared with (C) Socs1^lox/-Alb-cre mice. Note the swelling of hepatocytes that is not seen in Socs1^lox/-LysM-cre mice (Figure 2A). Collapsed hepatocytes (^*) and vacuole formation within hepatocytes (arrow) are also readily identifiable.