Figure 3.
Figure 3. Typical individual genome profiles of DLBCL cases. The individual genomic profile of 2 CD5-CD10- cases, 1 with an ABC signature (A) and the other with a GCB signature (B). Chr. indicates chromosome number. (A) Genomic gains are the following: 3p26.3-q12.3, 3q13.33-q29, 4q32.1-q35.1, 9p24.3-q22.33, 17p11.2-q21.1, 17q21.32, 17q23.2-q24.2, 18q, and Xp22.11-q28; genomic losses are the following: 9p21.3 (arrow), 13q14.3-q21.2, 15q21.3, 17p11.2-p13.3, and 17q21.33-q22. Note that loss of 9p21 occurred only at BAC, RP11-149I2 (arrow), which contains p16INK4a. (B) Genomic gains are the following: 1q21.3-q44, 2p13.2-p25.1, 7, 11q13.5-q25, 15q24.3-q26.3, 16, 21q, and X; genomic losses are the following: 1p36.22-p36.33, 1p13.1-p31.2, and 13q13.1-q14.3.

Typical individual genome profiles of DLBCL cases. The individual genomic profile of 2 CD5-CD10- cases, 1 with an ABC signature (A) and the other with a GCB signature (B). Chr. indicates chromosome number. (A) Genomic gains are the following: 3p26.3-q12.3, 3q13.33-q29, 4q32.1-q35.1, 9p24.3-q22.33, 17p11.2-q21.1, 17q21.32, 17q23.2-q24.2, 18q, and Xp22.11-q28; genomic losses are the following: 9p21.3 (arrow), 13q14.3-q21.2, 15q21.3, 17p11.2-p13.3, and 17q21.33-q22. Note that loss of 9p21 occurred only at BAC, RP11-149I2 (arrow), which contains p16INK4a. (B) Genomic gains are the following: 1q21.3-q44, 2p13.2-p25.1, 7, 11q13.5-q25, 15q24.3-q26.3, 16, 21q, and X; genomic losses are the following: 1p36.22-p36.33, 1p13.1-p31.2, and 13q13.1-q14.3.

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