Genome-wide frequency of the genomic imbalance in distinct DLBCL subtypes. Horizontal lines indicate 2213 BAC/PAC clones in order from chromosomes 1 to 22 and X. Within each chromosome, clones are shown in order from the p telomere to the q telomere according to information from the Ensemble Genome Data Resources of Sanger Center Institute, November 2004 version. Vertical lines indicate frequency (%) of gains and losses. (A) ABC group (28 cases), GCB group (18 cases), and ABC plus GCB (46 cases). (B) CD5⁺ group (36 cases), CD5^-CD10⁺ group (19 cases), and CD5^-CD10^- group (44 cases). The genomic imbalance characteristic of the CD5⁺ and CD5^-CD10⁺ groups was similar to those of the ABC and GCB groups, respectively. Frequency and region of the genomic imbalance of CD5^-CD10^- DLBCL showed patterns similar to that of ABC plus GCB.