Figure 6.
Genomic loss of 9p21.3, overall survival, and comparison of p16INK4agene expression in the ABC and GCB groups. (A) Kaplan-Meier analyses of survival of total cases, ABC cases, CD5+ cases, and CD5-CD10- cases either with or without 9p21.3 (p16INK4a locus) loss. (B) Representative individual genome profile of 9p21 in 3 cases. Dots represent the log2 ratio of BAC/PAC clones, which are shown in order from the p telomere to the q telomere. Bold lines under each profile indicate regions of loss. MCR indicates minimum common region of 9p loss. Vertical lines indicate log2 ratio; horizontal lines, megabases. Threshold of log2 ratio is -0.2 < log2 ratio < +0.2. (C) Comparison of p16INK4a expression in the ABC and GCB groups. Statistical significance of the difference was calculated using the Mann-Whitney U test. Horizontal bars indicate the mean value of relative level of expression.