Prognostic significance of the IgV mutation status and of the high-risk genomic aberrations 11q and 17p deletion in 211 chronic lymphocytic leukemia (CLL) patients. Among the 123 patients with unmutated IgV genes, those patients with high-risk genomic aberrations (n = 48) had a significantly inferior survival compared to the patients not exhibiting 11q- or 17p- (n = 75).