Intracellular concentrations of TGNs in patients after treatment with MP alone or in combination with MTX. Box plot of TGN concentrations in ALL cells for patients randomly assigned to treatment with MP alone (n = 33), HDMTX + MP (n = 20), or LDMTX + MP (n = 29). Horizontal line indicates the median for each group; box depicts the 25th and 75th percentile ranges. ⋄ indicates outlier values. P was determined by pairwise comparison using the Wilcoxon rank sum test adjusted for multiple testing.