Clustering of genes associated with intracellular concentrations of TGN in leukemia cells of patients treated with MP alone. (A) Hierarchical clustering of 33 ALL patients using 60 gene probe sets significantly associated with TGN accumulation in ALL cells after treatment with MP alone. Each row represents a probe set and each column a patient. Standardized expression values are shown according to the scale. Red and green symbols indicate patients with TGN concentrations higher and lower than 2.46 pmol/5 × 106 cells, respectively. Listed are the Affymetrix probe set IDs, gene names, GenBank accession numbers, and coefficients of correlation (rho). A positive rho indicates a positive correlation, and a negative rho indicates negative correlation between gene expression and intracellular TGN concentration. (B) PCA of ALL cells with high (red) and low (green) TGN concentrations based on the selected probe sets. Similarities are visualized in 3-dimensional space.
