Radich Figure 5 (Appelbaum et al).
Radich Figure 5 (Appelbaum et al). Flt3 internal tandem duplication (ITD). / 2A. The structure of normal Flt3. The ITD occurs in the juxta-membrane region (JM). / 2B. A Cartoon of the FLT3/ITD. A 20-200 bp region from exon 11-12 (blue box) is duplicated and inserted in a head-to-tail fashion. / 2C. PCR of AML samples. Amplification of wild type Flt3 yields a 320 bp PCR amplimer. The higher bands in sample 11, 12, and 14 are Flt3/ITDs.

Flt3 internal tandem duplication (ITD).

2A. The structure of normal Flt3. The ITD occurs in the juxta-membrane region (JM).

2B. A Cartoon of the FLT3/ITD. A 20-200 bp region from exon 11-12 (blue box) is duplicated and inserted in a head-to-tail fashion.

2C. PCR of AML samples. Amplification of wild type Flt3 yields a 320 bp PCR amplimer. The higher bands in sample 11, 12, and 14 are Flt3/ITDs.

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