Figure 6.
![Figure 6. P2Y-receptor–dependent conductance is permeable to Ca2+ and is amplified by phenylarsine oxide. (A) Representative ADP-evoked [Ca2+]i (top panel) increase and whole cell membrane currents at –70 mV in 0 Na+ (NMDG+), 0 Mg2+, 2.5 mM Ca2+ saline with 1 μM NF449. (B) Effect of a 2-minute preexposure to 15 μM phenylarsine oxide on the ADP-evoked membrane currents. (C) Average peak ADP-evoked currents in normal saline (150 mM Na, 1 mM Ca2+) and 2.5 mM Ca2+ saline (0 Na+, 0 Mg2+) with and without pretreatment of 15 μM PAO or 100 μM vanadate. Error bars indicate SEM. *Statistical significance of P < .05 when compared with control.](https://ash.silverchair-cdn.com/ash/content_public/journal/blood/106/5/10.1182_blood-2005-02-0725/6/zh80170583530006.jpeg?Expires=1735875119&Signature=TxaXtjykHhgrCfVgttrGCrxmScKJB4EOxOcFafiw79U9YM5vW6ku9DtDjlNqEyyOeTMWsdNGo5MSa5tFwUSF6OZxbqqhdojFrKJiSZ2sBgBbp1zHGTKiZznENSVNE7KjiPDM1rZiXdyx-7YpJI57YJ7I0QqhUAlQEMuUGxr94eINZ-GJ6hvZ6cV7EhAaoup4gNuvF-de7~IfkW2Vl4ZwZ7rIZV5a2Qd4VpP53hE4pkWYCiHPIdsO1bnoDUjrS70BhIL876uR4KaPV8bY8rS63Yi6NhzK8qd6ATs2ch2EVzsawt9tkTGmTi8bjFUiISIQs9ac8s-~M7aKQQQbUWn6sQ__&Key-Pair-Id=APKAIE5G5CRDK6RD3PGA)
P2Y-receptor–dependent conductance is permeable to Ca2+ and is amplified by phenylarsine oxide. (A) Representative ADP-evoked [Ca2+]i (top panel) increase and whole cell membrane currents at –70 mV in 0 Na+ (NMDG+), 0 Mg2+, 2.5 mM Ca2+ saline with 1 μM NF449. (B) Effect of a 2-minute preexposure to 15 μM phenylarsine oxide on the ADP-evoked membrane currents. (C) Average peak ADP-evoked currents in normal saline (150 mM Na, 1 mM Ca2+) and 2.5 mM Ca2+ saline (0 Na+, 0 Mg2+) with and without pretreatment of 15 μM PAO or 100 μM vanadate. Error bars indicate SEM. *Statistical significance of P < .05 when compared with control.
