Absolute T-cell counts in patients with ALL at diagnosis and during therapy. (A-B) Mean CD4 (A) and CD8 (B) T-cell counts for individual patients with respect to age (circles represent average values for all timepoints for each patient; ○ indicates standard-risk patients; •, high-risk patients). Boundaries for 10th to 90th percentiles for healthy children are indicated by the gray bands, and the dotted line represents the median. (C-D) T-cell counts over time. CD4 counts (C) and CD8 counts (D) in the cohort of patients are shown at diagnosis and at 5 points during therapy. Points represent median values and error bars interquartile range. Phases of treatment are shown by the bars below (▪ indicates induction; ▨, consolidation; and □, maintenance). Gray band represents 10th to 90th percentiles, and the dotted line represents the median for healthy children.