Figure 4.
![Figure 4. HNK overcomes the protective effects of IL-6, IGF-1, and adherence to patient BMSCs. MM.1S cells were treated for 48 hours with indicated concentrations of HNK in the presence or absence of IL-6 (A), IGF (B), or BMSCs derived from 2 patients with MM (C, D). DNA synthesis was determined by measuring [3H]-thymidine incorporation during the last 8 hours of 48-hour cultures. Values represent the mean plus or minus SD of triplicate cultures (*P < .05, **P < .05 inversely significant).](https://ash.silverchair-cdn.com/ash/content_public/journal/blood/106/5/10.1182_blood-2005-01-0346/6/zh80170583310004.jpeg?Expires=1735543955&Signature=nF3puM-EQ-3Omhny1VMDnHFhqqmeaXYWmkinHJe64lgJKhQIYBBxPyOvUeUtZitUq1ztNuzFNQF-On8fS5KG1dST8R5B8Uvhm1jK3Gp9~bt29zQgE6VFisMqhqOulZqaXA99N6zkna7nIv~P6XSwo0yjWE4V-fw6wT2dbN0et2pUjxwCzhe5zpJvOde5qDvF3dAUjNB2QZ5KdArypkMAwtS1txxF27~tzIck-Xe1ZGI-NnnDfZ2j0wbu46buE0ARfTrxM5ikQeISSwqUuLzrhO3xSbG5JV4uBvWN46BvymjH-GaZyE4L1wzfUvSIh6g-TDTYQ8u5IoEr9gOxuB7NhQ__&Key-Pair-Id=APKAIE5G5CRDK6RD3PGA)
HNK overcomes the protective effects of IL-6, IGF-1, and adherence to patient BMSCs. MM.1S cells were treated for 48 hours with indicated concentrations of HNK in the presence or absence of IL-6 (A), IGF (B), or BMSCs derived from 2 patients with MM (C, D). DNA synthesis was determined by measuring [3H]-thymidine incorporation during the last 8 hours of 48-hour cultures. Values represent the mean plus or minus SD of triplicate cultures (*P < .05, **P < .05 inversely significant).
