Figure 1.
Figure 1. Macroscopic and microscopic characterization of the spleens of M33- and Ad4BP/SF1-KO mice. Wild-type (A), M33-KO (B), SCID mouse (C), and Ad4BP/SF1-KO (D) spleens at 18.5 days after coitus are compared macroscopically. White arrowheads (B,D) indicate red spots characteristic of the M33- and Ad4BP/SF1-KO spleens. Stereomicroscopic images (A-D) were photographed with a Leica MZ APO (Leica, Wetzlar, Germany) using Photograb imaging solution (Fujifilm) and a Fuji HC-500 digital camera. Images were processed with Adobe Photoshop. Splenic tissue from wild-type (E,I), M33-KO (F,J), SCID mouse (G,K), and Ad4BP/SF1-KO (H,L) fetuses at 18.5 days after coitus were sectioned and stained with hematoxylin and eosin for microscopic observation. White arrows indicate assembled vascular structures. White arrowheads in panel E indicate hematoxylin-stained cells around the vasculatures. Scale bar, 800 μm (A-D), 100 μm (E-H), and 50 μm (I-L).

Macroscopic and microscopic characterization of the spleens of M33- and Ad4BP/SF1-KO mice. Wild-type (A), M33-KO (B), SCID mouse (C), and Ad4BP/SF1-KO (D) spleens at 18.5 days after coitus are compared macroscopically. White arrowheads (B,D) indicate red spots characteristic of the M33- and Ad4BP/SF1-KO spleens. Stereomicroscopic images (A-D) were photographed with a Leica MZ APO (Leica, Wetzlar, Germany) using Photograb imaging solution (Fujifilm) and a Fuji HC-500 digital camera. Images were processed with Adobe Photoshop. Splenic tissue from wild-type (E,I), M33-KO (F,J), SCID mouse (G,K), and Ad4BP/SF1-KO (H,L) fetuses at 18.5 days after coitus were sectioned and stained with hematoxylin and eosin for microscopic observation. White arrows indicate assembled vascular structures. White arrowheads in panel E indicate hematoxylin-stained cells around the vasculatures. Scale bar, 800 μm (A-D), 100 μm (E-H), and 50 μm (I-L).

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