Figure 2.
Figure 2. Defects in endothelial cells of M33-KO spleens. Vessel structures of wild-type (A,D,K), M33-KO (B,E,L), and Ad4BP/SF1-KO (C,F,M) spleens at 16.5 days after coitus were observed by electron microscopy. Boxed areas in panels A, C, E, and F are enlarged in G, H, I, and J, respectively. Arrows (B,C,H) and a square bracket (I) indicate extremely thin (∼ 30 nm) regions of the endothelial cells in the M33- and Ad4BP/SF1-KO spleens. Arrowheads (J) show collagen fibers. * indicates red blood cell; e, endothelial cell. Scale bar, 1 μm (A-F and K-M), 500 nm (G-J). Original magnification, 6000 × (A), 5000 × (B,D,E), 3500 × (C,K), 5000 × (D,E), 4000 × (F,L,M), 8000 × (G), and 10 000 × (H-J).

Defects in endothelial cells of M33-KO spleens. Vessel structures of wild-type (A,D,K), M33-KO (B,E,L), and Ad4BP/SF1-KO (C,F,M) spleens at 16.5 days after coitus were observed by electron microscopy. Boxed areas in panels A, C, E, and F are enlarged in G, H, I, and J, respectively. Arrows (B,C,H) and a square bracket (I) indicate extremely thin (∼ 30 nm) regions of the endothelial cells in the M33- and Ad4BP/SF1-KO spleens. Arrowheads (J) show collagen fibers. * indicates red blood cell; e, endothelial cell. Scale bar, 1 μm (A-F and K-M), 500 nm (G-J). Original magnification, 6000 × (A), 5000 × (B,D,E), 3500 × (C,K), 5000 × (D,E), 4000 × (F,L,M), 8000 × (G), and 10 000 × (H-J).

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