The risk of central nervous system (CNS) recurrence according to the number of risk factors (age, lactate dehydrogenase, albumin, number of extranodal sites, retroperitoneal involvement) in 1220 patients with high-grade non-Hodgkin’s lymphoma (NHL).

Reprinted with permission from Van Besien K, Ha CS, Murphy S, et al. Risk factors, treatment and outcome of central nervous system recurrence in adults with intermediate-grade and immunoblastic lymphoma. Blood. 1998;91:1178-1184.