Incidence of central nervous system (CNS) recurrence in patients with increased lactate dehydrogenase (LDH) and involvement of more than 1 extranodal site (n = 93; dotted line) versus all other patients (n = 512; solid line).

Reprinted with permission from Hollender A, Kvaloy S, Nome O, et al. Central nervous system involvement following diagnosis of non-Hodgkin’s lymphoma: a risk model. Ann Oncol. 2002;13:1099-1107.