Pathologic findings in the CNS of C57BL/6J mice immunized with MOG35-55. Control mice are shown in panels A-C, while animals treated at 3 and 8 days after immunization are shown in panels D-F. LFB staining of the spinal cord shows areas of demyelination (arrows) in control mice compared with MSC-treated mice (D) (4 ×). CD3⁺ T cells (B) and macrophages (C) infiltrating the spinal cord close to leptomeningeal vessels of control mice are shown (10 ×). Limited CD3⁺ T cells (E) and macrophages (F) are observed in the spinal cord from MSC-treated mice. Control mice were immunized with MOG35-55 and treated with intravenous PBS alone. Arrows indicate representative histological abnormalities.