American Society of Hematology

Figure 9.

$Figure 9. Nonmyeloablative conditioning with total lymphoid irradiation (TLI) and antithymocyte serum (ATS) protects mice against lethal graft-versus-host disease (GVHD). / The number of mice in each group was 10. / (A) Survival of mice conditioned with lethal total body irradiation (TBI) or TBI plus ATS and engrafted with allogeneic bone marrow (BM) or BM plus peripheral blood mononuclear cells (PBMC). TBI alone was lethal, and grafts containing PBMC resulted in death due to GVHD. / (B) Survival of mice conditioned with 4080 cGy of TLI and engrafted with BM or BM plus PBMC. TLI was nonmyeloablative, and TLI-conditioned mice showed some protection from lethal GVHD. / (C) Survival of mice conditioned with TLI plus ATS. All mice survived the conditioning and were protected from lethal GVHD. / Reprinted with permission from Lan F, Zeng D, Higuchi M, Huie P, Higgins JP, Strober S. Predominance of NK1.1+TCR alpha beta+ or DX5+TCR alpha beta+ T cells in mice conditioned with fractionated lymphoid irradiation protects against graft-versus-host disease: “natural suppressor” cells. J Immunol. 2001;167:2087-2096. Copyright 2001. The American Association of Immunologists, Inc.$

Nonmyeloablative conditioning with total lymphoid irradiation (TLI) and antithymocyte serum (ATS) protects mice against lethal graft-versus-host disease (GVHD).

The number of mice in each group was 10.

(A) Survival of mice conditioned with lethal total body irradiation (TBI) or TBI plus ATS and engrafted with allogeneic bone marrow (BM) or BM plus peripheral blood mononuclear cells (PBMC). TBI alone was lethal, and grafts containing PBMC resulted in death due to GVHD.

(B) Survival of mice conditioned with 4080 cGy of TLI and engrafted with BM or BM plus PBMC. TLI was nonmyeloablative, and TLI-conditioned mice showed some protection from lethal GVHD.

(C) Survival of mice conditioned with TLI plus ATS. All mice survived the conditioning and were protected from lethal GVHD.

Reprinted with permission from Lan F, Zeng D, Higuchi M, Huie P, Higgins JP, Strober S. Predominance of NK1.1+TCR alpha beta+ or DX5+TCR alpha beta+ T cells in mice conditioned with fractionated lymphoid irradiation protects against graft-versus-host disease: “natural suppressor” cells. J Immunol. 2001;167:2087-2096. Copyright 2001. The American Association of Immunologists, Inc.

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